Validity and reliability of CVI Range assessment for Clinical Research (CVI Range-CR): A longitudinal cohort study.

Chang M, Roman-Lantzy C, O’Neil SH, Reid, M. & Borchert, M. (2022). Validity and reliability of CVI Range assessment for Clinical Research (CVI Range-CR): A longitudinal cohort study. BMJ Open Ophthalmology. 7:e001144. https://doi.org/10.1136%2Fbmjophth-2022-001144

Grant support from (a)  Ingerman Foundation (MSB). (b) NIH NEI 1K23EY033790-01 (MC),(c) Saban Research Institute (MC), (d) Blind Children’s Center (MY), Children’s Eye Foundation of AAPOS (MY), (e) Knights Templar Eye Foundation (MC) and (f) Research to Prevent Blindness (MC and MSB). 

Purpose: Although several methods of assessing visual function and functional vision in children with cortical visual impairment (CVI) are used in clinical practice, none has been accepted as a standardized measure of CVI severity. The CVI Range is a functional vision assessment that is widely used but has undergone limited validation. 

Results: We developed a modified version of the CVI Range suitable for clinical research (CVI Range–Clinical Research (CVI Range- CR)) and will assess the inter-rater reliability and validity of the CVI Range- CR. Validation of the CVI Range-CR will enable this assessment to be incorporated in future clinical trials of treatments for CVI.

Advances in the evaluation and management of cortical/cerebral visual impairment in children.

Chang, MY & Borchert, MS (2020), 65:6, 708-724. Advances in the evaluation and management of cortical/cerebral visual impairment in children. Survey of Ophthalmology, 65:6, 708-724 https://doi.org/10.1016/j.survophthal.2020.03.001

Conducted with grant from Department of Ophthalmology at University of Southern California from Research to Prevent Blindness 

Purpose: Literature search of cortical/cerebral visual impairment (CVI) documenting what is known (published) about underlying etiologies, comorbidities, assessment of visual functioning, therapeutic approaches, etc. Article provides some suggestions for families and teachers and practitioners and includes an extensive list of references (peer-reviewed articles, reviews, books). 

Results: Topics covered include: 

• Characteristics of CVI in children 
• Visual evaluation (screening, visual function, electrophysiology, neuroimaging, functional neuroimaging, imaging of white matter tracts, genetic testing) 
• Management (prevention, visual stimulation, stem cell therapy, environmental modifications, treatment of ocular comorbidities, treatment of systemic comorbidities.